FEATURES OF MODAFINIL: SIDE EFFECTS YOU SHOULD KNOW

 

DRUG DESCRIPTION: 

Modafinil, commonly known as Provigil, is a central nervous system (CNS) stimulant medicine used to treat drowsiness brought on by insomnia, circadian rhythm sleep disorder, and upper airway obstruction. The evidence for this application currently needs to be clarified. However, it has been used off-label as a supposedly effective cognition booster to promote wakefulness in animals and humans. Provigil is a "nootropic" and is a member of the pharmacological class known as stimulants, CYP3AF Inducers.

Modafinil was initially developed in the 1970s by the French neurologist Michel Jouvet and Lafon Labs. The medicine has been recommended in France since 1994, and it was granted medical approval in the United States in 1998. In the United States, it is classified as a controlled substance of Schedule IV, even though this categorization has been called into question.

In the United Kingdom, one must have a doctor's prescription to purchase it. It is available to the public as a generic medication. In the United States of America in 2020, slightly more than one million prescriptions for the drug were written, placing it as the 302nd most often prescribed medicine.

In patients suffering from obstructive sleep apnea/hypopnea syndrome, this drug may be prescribed with breathing devices or other treatments to reduce the severity of excessive daytime sleepiness. The term "wakefulness-promoting agents" refers to the category of drugs that includes modafinil. It does this by altering the levels of certain naturally occurring chemicals in the brain region responsible for regulating sleeping and waking patterns.

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HOW TO USE MODAFINIL :

Modafinil is an oral pill with 100mg and 200mg strength. Typically, it is taken once a day, with or without a meal. Narcolepsy and OSAHS patients should take modafinil in the morning, whereas shift workers with SWSD should take it an hour before their shift starts. Take it every day at the same time. Do not alter the timing of your medication without first consulting with your primary care physician. Take modafinil as prescribed by your doctor.

It might become a habit. Never exceed the recommended dosage, alter the frequency of administration, or take it for an extended period. Modafinil may make you less sleepy, but it won't treat your sleep issue. Modafinil is usually given for 12 weeks or less. Without consulting your doctor, do not discontinue or extend taking the drug.

It shouldn't be substituted for getting enough rest. Obey your doctor's recommendations for sound sleeping practices. If you have OSAHS, in particular, continue to utilize any breathing aids or other therapies that your doctor has advised.

Modafinil should be taken in increments of 100 mg, 150 mg, 200 mg, 300 mg, and 400 mg. If a dose is missed, the patient should wait until the next scheduled dose before retaking the medication. It is essential to avoid taking a second dose to make up for the one you missed. If you consume modafinil later during the day, you could have trouble falling or staying asleep at night.

SIDE EFFECTS OF MODAFINIL:

Keep in mind that your doctor has recommended that you take this medication because they believe the potential benefits outweigh the risks. Most persons who take this medicine do not report experiencing any severe adverse effects.

Modafinil has a few adverse side effects, although it is one of the safest nootropics. There is a possibility that some of these negative effects will call for medical treatment while others might not. If you encounter serious adverse effects, you should contact your doctor immediately.

Commonly occurring side effects:

·         Nausea
·         Headache
·         Anxiety
·         Nervousness
·         Heartburn
·         Loss of appetite
·         Unusual tastes
·         Excessive thirst and dehydration
·         Nosebleed
·         Flushing and Sweating
·         Tight muscles or difficulty moving
·         Back pain
·         Difficulty seeing or eye discomfort
·         Uncontrollable shaking of a part of your body
·         Burning, tingling, or numbness of the skin
·         Difficulty seeing or eye discomfort

The following adverse effects have been reported: under 10 percent of patients reported experiencing migraine, dizziness, and decreased appetite. Anxiety, sleeplessness, headache, diarrhea, and rhinitis are all potential side effects that could affect between 5 and 10 percent of users.

In clinical trials, no clinically significant alterations in physical mass have been found; nevertheless, reduced hunger and fat loss have been recorded in children and adolescents. This is likely owing to these individuals' significantly higher Provigil intake based on their body weight.

Long-Term or Severe Side Effects:

Tell your doctor if you experience any of the following effects.

·         Rash
·         Blisters
·         Peeling skin
·         Mouth sores
·         Hives
·         Itching
·         Hoarseness
·         Difficulty breathing or swallowing
·         Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
·         Chest pain
·         Fast, pounding, or irregular heartbeat
·         Frenzied, abnormally excited mood
·         Hallucinating (seeing things or hearing voices that do not exist)
·         Anxiety
·         Depression
·         Thinking about killing or harming yourself(suicidal thoughts)

It is unusual for this medicine to cause an extremely severe allergic reaction. However, you should seek immediate medical attention if you experience any indications of an extreme allergic response, such as a high temperature, swollen lymph nodes, a rash, or itchy skin.

The following severe adverse reactions are described elsewhere in the labeling:

• Severe Rash, including Stevens-Johnson Syndrome
• Anaphylaxis Reaction and Angioedema
• Multi-organ Hypersensitivity Reactions
• Psychiatric Symptoms
• Effects on Ability to Drive and Use Machinery
• Cardiovascular Events

The rates of side effects seen in the clinical trials of one drug can't be directly compared to that of another drug, and they may not be the same as the rates seen in real life. This is due to the conditions under which clinical trials are conducted being very distinct.

Some people experience dose-dependent side effects of modafinil, including headaches and nausea (200 mg, 300 mg, and 400 mg, respectively).

There have been infrequent reports of more serious adverse effects, such as severe skin rashes and other symptoms that are most likely allergy-related. These negative effects have been documented. The United States Food and Drug Administration (FDA) reported receiving six cases of severe dermal allergic events associated with modafinil between the date of initial marketing in December 1998 and January 30, 2007.

These reactions included erythema multiforme, Stevens–Johnson syndrome, and toxic epidermal necrolysis, affecting adult and pediatric patients. The FDA issued an important warning. Angioedema and multi-organ hypersensitivity events have also been recorded in post-marketing experiences.

It has yet to be known whether modafinil is safe and effective when used over a prolonged period. However, a recent longitudinal study in pediatric patients treated for narcolepsy for up to ten years demonstrated that modafinil and armodafinil were safe and effective. The study concluded that using modafinil and armodafinil significantly improved the patient's ability to stay awake and did not exacerbate any pre-existing psychiatric conditions.

 

Laboratory Abnormalities:

In the investigations, measurements from clinical chemistry, hematology, and urine were taken at regular intervals. It was discovered that the average plasma concentration of gamma-glutamyl transferase (GGT) and alkaline phosphatase (AP) increased after the administration of PROVIGIL, but this was not the case after the administration of the placebo.

However, only a small number of patients showed GGT or AP elevations outside the standard parameters. During the placebo-controlled clinical studies, the group treated with PROVIGIL appeared to experience shifts over time toward higher GGT and AP values that did not demonstrate clinically significant abnormalities. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, or total bilirubin did not alter in any way.

 

DEPENDENCE AND ADDICTION:

The risk of becoming addicted to modafinil and dependent on it is minimal. Some investigations have found that it has similar mood-elevating characteristics, albeit somewhat, and shares biological processes with addictive stimulant medications.

 It is unclear whether these effects are any different or comparable to those caused by caffeine. It does not appear that Provigil produces euphoric effects, nor does it seem to cause deviations from the dosages that are provided to the patient. The Food and Drug Administration (FDA) in the United States has placed it in the category of prohibited substances known as schedule IV, which is reserved for medications that have established clinical use but have a low potential for addiction.

According to the International Narcotics Control Board, it does not meet the criteria for classification as either a narcotic or a psychotropic substance. The drug may improve abstinence rates in a subgroup of cocaine users, despite modafinil-related cessation side effects being identical to those of a placebo.

NOTES:

You mustn't provide this medication to anyone else. It is against the law to give it away.

You may be subjected to periodic laboratory and/or medical tests (such as monitoring your blood pressure and heart rate, for example) to track your progress or look for any adverse effects. Consult your doctor for additional details.

If you have a shift work sleep problem, then developing healthy sleep routines (such as sleeping in a dark and quiet room and avoiding coffee close tonight) can help improve the quality of your sleep and make it easier for you to fall asleep and stay asleep.